Automated Dicentric Chromosome Identifier
and Radiation Dose Estimator
frequently asked questions
There are many differences.
ADCI is fully automated. Input are digital images - output are estimated dose with confidence intervals. Please view our 10 minute video available in the Journal of Visualized Experiments (JoVE) for a brief demonstration of the software.
It is also fast, but gives accurate doses above 1 Gy. The online manual indicates the processing speed on a Intel I7 equipped laptop computer (view time required to process a variety of samples). This makes it possible to process batches of samples which would be necessary in a mass casualty event. We have developed a high performance computing version of the software, but it is not yet ready for commercial release.
Manual review and cell exclusion is still allowed, but is not necessary. Metasystems DCScore hasn't been updated since it was released in 2004 and requires manual review. It doesn't handle bent or twisted chromosomes as well as ADCI. Furthermore, it does not exclude overlapped chromosomes, which leads to inflated DC counts. ADCI separates touching chromosomes with the watershed algorithm and ignores overlapped chromosomes, unless they are so abundant in an images due to poor spreading, that the image is not selected by our automated methods (see F1000Research paper).